Burman, J;
Raininko, R;
Blennow, K;
Zetterberg, H;
Axelsson, M;
Malmestrom, C;
(2016)
YKL-40 is a CSF biomarker of intrathecal inflammation in secondary progressive multiple sclerosis.
Journal of Neuroimmunology
, 292
pp. 52-57.
10.1016/j.jneuroim.2016.01.013.
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Abstract
YKL-40 (CHI3L1) is a glycoprotein predominantly produced by reactive astrocytes in chronic active MS lesions, which are common in secondary progressive MS. In this study, YKL-40 was investigated in different stages of MS and in relation to MRI findings. YKL-40 levels in CSF samples from two independent patient cohorts of MS patients were determined with ELISA. CSF YKL-40 was increased in patients with active relapsing–remitting MS and correlated with the number of gadolinium enhancing lesions. Patients with secondary progressive MS had similar high levels of YKL-40, whereas not active relapsing–remitting MS patients had YKL-40 levels comparable to healthy controls.
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