Oliva, A;
Fernandez-Ruiz, A;
de Oliveira, EF;
Buzsaki, G;
(2018)
Origin of Gamma Frequency Power during Hippocampal Sharp-Wave Ripples.
Cell Reports
, 25
(7)
1693-1700.e4.
10.1016/j.celrep.2018.10.066.
Preview |
Text
1-s2.0-S221112471831670X-main.pdf - Published Version Download (5MB) | Preview |
Abstract
Hippocampal sharp-wave ripples (SPW-Rs) support consolidation of recently acquired episodic memories and planning future actions by generating ordered neuronal sequences of previous or future experiences. SPW-Rs are characterized by several spectral components: a slow (5–15 Hz) sharp-wave, a high-frequency “ripple” oscillation (150–200 Hz), and a slow “gamma” oscillation (20–40 Hz). Using laminar hippocampal recordings and optogenetic manipulations, we dissected the origin of these spectral components. We show that increased power in the 20–40 Hz band does not reflect an entrainment of CA1 and CA3 neurons at gamma frequency but the power envelope of overlapping ripples. Spike-local field potential coupling between unit firing in CA1 and CA3 regions during SPW-Rs is lowest in the gamma band. Longer SPW-Rs are preceded by increased firing in the entorhinal cortex. Thus, fusion of SPW-Rs leads to lengthening of their duration associated with increased power in the slow gamma band without the presence of true oscillation.
| Type: | Article |
|---|---|
| Title: | Origin of Gamma Frequency Power during Hippocampal Sharp-Wave Ripples |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.celrep.2018.10.066 |
| Publisher version: | http://doi.org/10.1016/j.celrep.2018.10.066 |
| Language: | English |
| Additional information: | Copyright © 2018 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | hippocampus, oscillations, memory consolidation, sharp-wave ripples,gamma, entorhinal cortex, optogenetics |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10070642 |
Archive Staff Only
 |
View Item |
