Enriquez-Marulanda, A;
Sierra-Ruiz, M;
Jaramillo, FJ;
Escobar, LA;
Granados, AM;
Rodríguez-Rojas, LX;
Lees, AJ;
(2017)
Hemichoreo-hemibalism as a Manifestation of Central Nervous System Chronic Graft-versus-Host Disease.
Movement Disorders Clinical Practice
, 4
(4)
pp. 495-498.
10.1002/mdc3.12497.
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Abstract
Hematopoietic stem cell transplantation (HSCT) is an effective treatment modality for many life‐threatening diseases that were once considered incurable.1, 2 This therapy has evolved rapidly during the last few decades due to immunologic advances and progress in stem cell technology; currently, more than 60,000 HSCTs are carried out annually worldwide.2 In the first few years of using this therapy, patients survived only for a few months, despite successful grafts and remissions of the malignancies, due to complications that arose soon after transplantation, including severe bleeding or severe infections caused by thrombocytopenia or neutropenia, respectively.2 Recently, transplantation‐related mortality soon after transplantation decreased because of the introduction of reduced‐intensity conditioning regimens and more effective anti‐infectious agents.3, 4 Unfortunately, complications arising a longer period after transplantation, such as graft‐versus‐host disease (GVHD), has begun to emerge. These are even more problematic than early onset complications, because poor progress has been made in decreasing late transplantation‐related mortalities.3 Here, we report a case of chronic GVHD (cGVHD) of the central nervous system (CNS) presenting as hemichorea‐hemiballismus.
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