Margrie, T;
Brown, APY;
Cossell, L;
(2019)
Visual experience regulates the intrinsic excitability of visual cortical neurons to maintain sensory function.
Cell Reports
, 27
(3)
pp. 685-689.
10.1016/j.celrep.2019.03.073.
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Abstract
This in vivo study shows that both intrinsic and sensory-evoked synaptic properties of layer 2/3 neurons in mouse visual cortex are modified by ongoing visual input. Following visual deprivation, intrinsic properties are significantly altered, although orientation selectivity across the population remains unchanged. We, therefore, suggest that cortical cells adjust their intrinsic excitability in an activity-dependent manner to compensate for changes in synaptic drive and maintain sensory network function
| Type: | Article |
|---|---|
| Title: | Visual experience regulates the intrinsic excitability of visual cortical neurons to maintain sensory function |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.celrep.2019.03.073 |
| Publisher version: | https://doi.org/10.1016/j.celrep.2019.03.073 |
| Language: | English |
| Additional information: | Copyright © 2019 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | visual cortex; layer 2/3; intrinsic properties; dark rearing; orientation selectivity |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10069819 |
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