Leira, Y;
Iglesias-Rey, R;
Gómez-Lado, N;
Aguiar, P;
Campos, F;
D'Aiuto, F;
Castillo, J;
... Sobrino, T; + view all
(2019)
Porphyromonas gingivalis lipopolysaccharide-induced periodontitis and serum amyloid-beta peptides.
Archives of Oral Biology
, 99
pp. 120-125.
10.1016/j.archoralbio.2019.01.008.
Preview |
Text
Leira et al. 2019. AOB.pdf - Published Version Download (756kB) | Preview |
Abstract
Objective The aim of this investigation was to determine the circulating levels of amyloid beta (Aβ) peptides using the Porphyromonas gingivalis (Pg) lipopolysaccharide (LPS) model to induce periodontitis. Methods Experimental periodontitis was induced in 6 male Sprague-Dawley rats. Alveolar bone loss was measure by micro computed tomography. Serum concentrations of Aβ1–40 and Aβ1–42 prior to periodontal induction, at 24 h, 7, 14, and 21 days the last injection of Pg-LPS. Results The distance between the cemento-enamel junction and the bone crest (i.e., alveolar bone loss) was significantly higher at the end of periodontal induction compared to baseline (2.92 ± 0.29 mm vs. 3.8 ± 0.28 mm, P < 0.001). Periodontitis evoked a slight acute elevation of Aβ1–40 serum levels that were maintained during the whole experiment. Aβ1–42 peptide levels peak at the end of the study. A positive strong correlation was observed between alveolar bone loss and Aβ1–40 serum levels at 7 days (r = 0.695, P = 0.012) and as well as with serum Aβ1–42 concentrations at 21 days (r = 0.968, P = 0.002). Conclusions Periodontitis induced Pg-LPS produced increased serum levels of Aβ peptides. Further studies are needed to confirm our results and to investigate the mechanisms by which periodontitis could be associated with an overexpression of Aβ.
| Type: | Article |
|---|---|
| Title: | Porphyromonas gingivalis lipopolysaccharide-induced periodontitis and serum amyloid-beta peptides |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.archoralbio.2019.01.008 |
| Publisher version: | https://doi.org/10.1016/j.archoralbio.2019.01.008 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Periodontitis Lipopolysaccharide Porphyromonas gingivalis Amyloid-beta peptides Endothelial dysfunction Cognitive decline |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Restorative Dental Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10069761 |
Archive Staff Only
 |
View Item |
