Rubin, LH;
Tierney, R;
Kawata, K;
Wesley, L;
Lee, JH;
Blennow, K;
Zetterberg, H;
(2019)
NFL blood levels are moderated by subconcussive impacts in a cohort of college football players.
Brain Injury
, 33
(4)
pp. 456-462.
10.1080/02699052.2019.1565895.
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Abstract
INTRODUCTION: Repetitive subconcussive head impacts in contact/collision sports such as in US football are believed to contribute to long-term brain changes and chronic symptoms. However, the lack of tools to measure the effects of repeated subconcussion limits our understanding of potential contributions to neuropathological alterations including cellular damage. // METHODS: We examined subconcussive head impacts using an accelerometer-embedded mouthguard on changes in blood levels of neurofilament light (NFL) chain in 18 Division I college football players. Plasma levels of NFL and clinical symptoms were assessed at pre-post practices. The frequency and linear and rotational head accelerations recorded via the mouthguard were examined in relation to NFL plasma changes. // RESULTS: The frequency and magnitude of head impacts associated with increased NFL levels. The greater numbers of hits and head accelerations associated with greater pre- to post-practice NFL level increases (p < 0.05). Greater pre- to post-practice increases in NFL also associated with greater pre- to post-practice increases in S100β (p < 0.001), but not with total tau. Years of football experience and concussion history did not associate with changes in NFL. // CONCLUSION: Acute changes in NFL may be a clinically useful peripheral marker in tracking acute brain damage in collegiate football players, and other contact sports.
| Type: | Article |
|---|---|
| Title: | NFL blood levels are moderated by subconcussive impacts in a cohort of college football players |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/02699052.2019.1565895 |
| Publisher version: | https://doi.org/10.1080/02699052.2019.1565895 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Subconcussive, biomarker, head impact kinematics, neurofilament light chain, traumatic brain injury |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10069670 |
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