Brown, CN;
Green, BD;
Thompson, RB;
den Hollander, AI;
Lengyel, I;
Acar, IE;
Ajana, S;
... Zumbansen, M; + view all
(2019)
Metabolomics and Age-Related Macular Degeneration.
Metabolites
, 9
(1)
, Article 4. 10.3390/metabo9010004.
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Abstract
Age-related macular degeneration (AMD) leads to irreversible visual loss, therefore, early intervention is desirable, but due to its multifactorial nature, diagnosis of early disease might be challenging. Identification of early markers for disease development and progression is key for disease diagnosis. Suitable biomarkers can potentially provide opportunities for clinical intervention at a stage of the disease when irreversible changes are yet to take place. One of the most metabolically active tissues in the human body is the retina, making the use of hypothesis-free techniques, like metabolomics, to measure molecular changes in AMD appealing. Indeed, there is increasing evidence that metabolic dysfunction has an important role in the development and progression of AMD. Therefore, metabolomics appears to be an appropriate platform to investigate disease-associated biomarkers. In this review, we explored what is known about metabolic changes in the retina, in conjunction with the emerging literature in AMD metabolomics research. Methods for metabolic biomarker identification in the eye have also been discussed, including the use of tears, vitreous, and aqueous humor, as well as imaging methods, like fluorescence lifetime imaging, that could be translated into a clinical diagnostic tool with molecular level resolution.
| Type: | Article |
|---|---|
| Title: | Metabolomics and Age-Related Macular Degeneration |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/metabo9010004 |
| Publisher version: | https://doi.org/10.3390/metabo9010004 |
| Language: | English |
| Additional information: | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | age-related macular degeneration, metabolomics, metabolism, biomarkers, drusen, retinal pigment epithelium |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10069344 |
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