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Spontaneous Generation of Patient-Specific Retinal Pigment Epithelial Cells Using Induced Pluripotent Stem Cell Technology

Carter, DA; Nommiste, B; Coffey, PJ; Carr, AF; (2016) Spontaneous Generation of Patient-Specific Retinal Pigment Epithelial Cells Using Induced Pluripotent Stem Cell Technology. In: Ulrich, U and Davidson Negraes, P, (eds.) Working with Stem Cells. (pp. 143-161). Springer: Cham, Switzerland. Green open access

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Abstract

Stem cell technology has a number potential uses when it comes to the eye, particularly disease and developmental modelling, and as potential therapeutic source. A variety of protocols have been developed that facilitate the generation of the different cell types found within the eye, as well as those that produce a facsimile of the developing eye in vitro. This chapter introduces the importance of the Retinal Pigment Epithelium (RPE) in maintaining visual function. We then focus on methods developed by our group to produce RPE from patient skin samples using human induced pluripotent stem cell technology (iPSC).

Type: Book chapter
Title: Spontaneous Generation of Patient-Specific Retinal Pigment Epithelial Cells Using Induced Pluripotent Stem Cell Technology
ISBN: 3319305808
ISBN-13: 9783319305806
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-3-319-30582-0_9
Publisher version: https://doi.org/10.1007/978-3-319-30582-0_9
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Human induced pluripotent stem cells, Retinal pigment epithelium, Transplantation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10069028
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