Carter, DA;
Nommiste, B;
Coffey, PJ;
Carr, AF;
(2016)
Spontaneous Generation of Patient-Specific Retinal Pigment Epithelial Cells Using Induced Pluripotent Stem Cell Technology.
In: Ulrich, U and Davidson Negraes, P, (eds.)
Working with Stem Cells.
(pp. 143-161).
Springer: Cham, Switzerland.
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Abstract
Stem cell technology has a number potential uses when it comes to the eye, particularly disease and developmental modelling, and as potential therapeutic source. A variety of protocols have been developed that facilitate the generation of the different cell types found within the eye, as well as those that produce a facsimile of the developing eye in vitro. This chapter introduces the importance of the Retinal Pigment Epithelium (RPE) in maintaining visual function. We then focus on methods developed by our group to produce RPE from patient skin samples using human induced pluripotent stem cell technology (iPSC).
| Type: | Book chapter |
|---|---|
| Title: | Spontaneous Generation of Patient-Specific Retinal Pigment Epithelial Cells Using Induced Pluripotent Stem Cell Technology |
| ISBN: | 3319305808 |
| ISBN-13: | 9783319305806 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/978-3-319-30582-0_9 |
| Publisher version: | https://doi.org/10.1007/978-3-319-30582-0_9 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Human induced pluripotent stem cells, Retinal pigment epithelium, Transplantation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10069028 |
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