Genes and pathways in optic fissure closure

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Genes and pathways in optic fissure closure

Patel, A; Sowden, JC; (2017) Genes and pathways in optic fissure closure. Seminars in Cell and Developmental Biology 10.1016/j.semcdb.2017.10.010. (In press). Green open access

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Abstract

Embryonic development of the vertebrate eye begins with the formation of an optic vesicle which folds inwards to form a double-layered optic cup with a fissure on the ventral surface, known as the optic fissure. Closure of the optic fissure is essential for subsequent growth and development of the eye. A defect in this process can leave a gap in the iris, retina or optic nerve, known as a coloboma, which can lead to severe visual impairment. This review brings together current information about genes and pathways regulating fissure closure from human coloboma patients and animal models. It focuses especially on current understanding of the morphological changes and processes of epithelial remodelling occurring at the fissure margins.

Type:	Article
Title:	Genes and pathways in optic fissure closure
Location:	England
Open access status:	An open access version is available from UCL Discovery
DOI:	10.1016/j.semcdb.2017.10.010
Publisher version:	https://doi.org/10.1016/j.semcdb.2017.10.010
Language:	English
Additional information:	This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords:	Optic fissure, Coloboma, Colobomos, Eye development, Congenital eye malformation
UCL classification:	UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI:	https://discovery.ucl.ac.uk/id/eprint/10068929

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