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On-Probe Neural Interface ASIC for Combined Electrical Recording and Optogenetic Stimulation

Ramezani, R; Liu, Y; Dehkhoda, F; Soltan, A; Haci, D; Zhao, H; Firfilionis, D; ... Degenaar, P; + view all (2018) On-Probe Neural Interface ASIC for Combined Electrical Recording and Optogenetic Stimulation. IEEE Transactions on Biomedical Circuits and Systems , 12 (3) pp. 576-588. 10.1109/TBCAS.2018.2818818. Green open access

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Abstract

Neuromodulation technologies are progressing from pacemaking and sensory operations to full closed-loop control. In particular, optogenetics-the genetic modification of light sensitivity into neural tissue allows for simultaneous optical stimulation and electronic recording. This paper presents a neural interface application-specified integrated circuit (ASIC) for intelligent optoelectronic probes. The architecture is designed to enable simultaneous optical neural stimulation and electronic recording. It provides four low noise (2.08 μV rms ) recording channels optimized for recording local field potentials (LFPs) (0.1-300 Hz bandwidth, ± 5 mV range, sampled 10-bit@4 kHz), which are more stable for chronic applications. For stimulation, it provides six independently addressable optical driver circuits, which can provide both intensity (8-bit resolution across a 1.1 mA range) and pulse-width modulation for high-radiance light emitting diodes (LEDs). The system includes a fully digital interface using a serial peripheral interface (SPI) protocol to allow for use with embedded controllers. The SPI interface is embedded within a finite state machine (FSM), which implements a command interpreter that can send out LFP data whilst receiving instructions to control LED emission. The circuit has been implemented in a commercially available 0.35 μm CMOS technology occupying a 1.95 mm × 1.10 mm footprint for mounting onto the head of a silicon probe. Measured results are given for a variety of bench-top, in vitro and in vivo experiments, quantifying system performance and also demonstrating concurrent recording and stimulation within relevant experimental models.

Type: Article
Title: On-Probe Neural Interface ASIC for Combined Electrical Recording and Optogenetic Stimulation
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/TBCAS.2018.2818818
Publisher version: http://doi.org/10.1109/TBCAS.2018.2818818
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 3.0 License. For more information, see http://creativecommons.org/licenses/by/3.0/
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
URI: https://discovery.ucl.ac.uk/id/eprint/10067915
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