Romandini, M;
De Tullio, I;
Congedi, F;
Kalemaj, Z;
D'Ambrosio, M;
Laforí, A;
Quaranta, C;
... Perfetti, G; + view all
(2019)
Antibiotic prophylaxis at dental implant placement: Which is the best protocol? A systematic review and network meta‐analysis.
Journal of Clinical Periodontology
, 46
(3)
pp. 382-395.
10.1111/jcpe.13080.
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Abstract
AIM: This systematic review of randomized controlled trials (RCTs) aims to answer to the following question: "In patients undergoing dental implant placement, which is the best antibiotic prophylaxis protocol to prevent early failures?". MATERIALS AND METHODS: The MEDLINE, SCOPUS, CENTRAL and Web of Knowledge electronic databases were searched in duplicate for RCTs up to July 2017. Additional relevant literature was identified through 1) hand-searching on both relevant journals and on reference lists, and 2) searching in databases for grey literature. A Network Meta-analysis (NMA) was conducted and the probability that each protocol is the "Best" was estimated. RESULTS: Nine RCTs were included, with a total of 1,693 participants. Due to the few events reported, it was not possible to conduct a NMA for adverse events, therefore it was conducted only for implant failures (IF). The protocol with the highest probability (32.5%) of being the "Best" one to prevent IF was the single dose of 3g of amoxicillin administered 1-h pre-operatively. Even if the single pre-operative dose of 2g of amoxicillin is the most used, it achieved only a probability of 0.2% to be the "Best" one. CONCLUSIONS: Basing on the available RCTs, the use of antibiotic prophylaxis is protective against early implant failures, but there is still insufficient evidence to confidently recommend a specific dosage. The use of post-operative courses does not seem however to be justified by the available literature.
| Type: | Article |
|---|---|
| Title: | Antibiotic prophylaxis at dental implant placement: Which is the best protocol? A systematic review and network meta‐analysis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/jcpe.13080 |
| Publisher version: | https://doi.org/10.1111/jcpe.13080 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Adverse Events, Antibiotic Prophylaxis, Early Failures, Early Implant Failures, Implant Placement, Implant Survival, Network Meta-Analysis, Penicillins, Side Effects, Systematic Review |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Restorative Dental Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10067880 |
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