Abbosh, C;
Venkatesan, S;
Janes, SM;
Fitzgerald, RC;
Swanton, C;
(2017)
Evolutionary dynamics in pre-invasive neoplasia.
Current Opinion in System Biology
, 2
pp. 1-8.
10.1016/j.coisb.2017.02.009.
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Abstract
Mutational processes occur in normal tissues from conception throughout life. Field cancerization describes the preconditioning of an area of epithelium to tumor growth. Pre-invasive lesions may arise in these fields, however only a minority of pre-invasive neoplasia progresses to overt malignancy. Within this review we discuss recent advances in our understanding of genomic instability processes in normal tissue, describe evolutionary dynamics in pre-invasive disease and highlight current evidence describing how increasing genomic instability may drive the transition from pre-invasive to invasive disease. Appreciation of the evolutionary rulebooks that operate in pre-invasive neoplasia may facilitate screening strategies, risk-stratification of pre-invasive lesions and precipitate novel preventative treatments in at-risk patient populations.
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