Rosa Duque, JS;
Cheuk, DKL;
Chong, PCY;
Ip, P;
Wong, WHS;
Wong, ICK;
Chan, GCF;
... Ho, MHK; + view all
(2019)
Risk Factors for Drug Allergies in Chinese Children.
Asian Pacific Journal of Allergy and Immunology
10.12932/AP-191018-0417.
(In press).
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Abstract
BACKGROUND: Drug allergy, or drug hypersensitivity, is a potentially fatal disorder, and patients labeled with drug allergies have restricted access to first-line treatments. Full knowledge of the characteristics associated with drug allergies and severe reactions during allergy evaluation is beneficial for appropriate risk stratification. OBJECTIVE: We sought to determine whether certain clinical characteristics are associated with drug allergies in Chinese children. METHODS: Charts were reviewed for ethnic Chinese patients less than 18 years old referred to our tertiary allergy center for suspected drug allergies and completed skin and drug provocative testing between 2005 to 2017. Univariate and multivariate analyses were performed on the age of onset of drug allergies, gender, and other atopy versus drug allergies. RESULTS: Out of 75 children, 18 (24%) had IgE-mediated drug allergies, while 8 (10.7%) had delayed drug hypersensitivities, with a cumulative 26 subjects (34.7%) with any drug hypersensitivity. There were positive independent associations between drug hypersensitivities onset age vs IgE-mediated drug allergies (odds ratio (OR)=14.9, 95% confidence intervals (CIs)=1.5-148.3, P=0.017) and between male gender and IgE-mediated drug allergies (OR=4.4, CIs=1.2-16.4, P=0.019). Age 13 years was the best cut-off for IgE-mediated drug allergies according to the receiver operating characteristic curve (P=0.026). Older age group (OR=24.0, CIs=1.4-417.8, P=0.024) and atopic dermatitis (OR=8.2, CIs=1.4-49.8, P=0.015) were correlated with delayed drug hypersensitivities. CONCLUSIONS: While several previous studies suggested a higher prevalence of IgE-mediated drug allergies in younger adult females, older boys were more likely to have drug allergies for Chinese children.
| Type: | Article |
|---|---|
| Title: | Risk Factors for Drug Allergies in Chinese Children |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.12932/AP-191018-0417 |
| Publisher version: | https://doi.org/10.12932/AP-191018-0417 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | allergy, anaphylaxis, challenge, drug, epidemiology, IgE, paediatric, pharmacogenomics, pharmacology, provocative, skin testing |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10065988 |
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