Zetterberg, H;
(2017)
Psychosis and biological markers.
[Editorial comment].
Lancet Psychiatry
, 4
(1)
pp. 3-5.
10.1016/S2215-0366(16)30407-2.
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Abstract
In The Lancet Psychiatry, Belinda R Lennox and colleagues present a report in which 228 patients with first-episode psychosis were compared with 105 healthy control individuals regarding prevalence of serum autoantibodies to neuronal surface antigens. Serum NMDA receptor (NMDAR) antibodies were specifically seen in patients with first-episode psychosis (not healthy controls) without any clear association to phenotypic characteristics of the patients. When looking for biological markers to evaluate a disease, knowledge of the pathology or pathophysiology aids biomarker discovery and increases the interpretability of the results generated during the discovery process. In psychiatry, the clear and abundant pathology of Alzheimer's disease has facilitated the development of imaging and fluid biomarkers for the disease.2 For schizophrenia and several other central nervous system diseases, this process has been much harder.
| Type: | Article |
|---|---|
| Title: | Psychosis and biological markers |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/S2215-0366(16)30407-2 |
| Publisher version: | https://doi.org/10.1016/S2215-0366(16)30407-2 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10065859 |
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