Perry, H;
Stirrup, O;
Gutierrez, J;
Vinayagam, D;
Thilaganathan, B;
Khalil, A;
(2019)
Influence of maternal characteristics and gestational age on haemodynamic indices: NICOM device-specific reference ranges.
Ultrasound in Obstetrics and Gynaecology
, 54
(5)
pp. 670-675.
10.1002/uog.20179.
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Abstract
BACKGROUND: There is increasing evidence for the importance of haemodynamic monitoring in pregnancy. Device-specific reference ranges are required in order to correctly intepret hemodynamic indices in healthy and pathological pregnancies. METHODS: This was a prospective cohort study of healthy singleton pregnancies. Haemodynamic measurements of stroke volume, cardiac output and systemic vascular resistance throughout pregnancy were obtained using NICOM® , a non-invasive device based on bio-reactance technology. NICOM device-specific reference ranges were created with respect to gestational age and maternal characteristics. RESULTS: We included 411 women in this study. The relationships shown between cardiac variables and gestational age shown in the NICOM-specific reference ranges are consistent with previous findings, with an increase in cardiac output until around 35 weeks before a decrease to term and converse changes in systemic vascular resitance. Maternal weight, height and age were associated with cardiac output (all p<0.05) and systemic vascular resistance (all p<0.01), whilst maternal weight and height were associated with stroke volume (both p<0.001). Ethnicity was significantly associated with stroke volume (p<0.05) but not with cardiac output or systemic vascular resistance. CONCLUSIONS: This study presents device-specific reference ranges for stroke volume, cardiac output and systemic vascular resistance for the NICOM® device in pregnancy and describes the maternal characteristics that are associated with the values of these haemodynamic measurements. Studies using NICOM® in pregnancy can use these ranges in order to evaluate observations relative to those expected in uncomplicated pregnancies conditional on maternal characteristics. This article is protected by copyright. All rights reserved.
| Type: | Article |
|---|---|
| Title: | Influence of maternal characteristics and gestational age on haemodynamic indices: NICOM device-specific reference ranges |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/uog.20179 |
| Publisher version: | https://doi.org/10.1002/uog.20179 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | maternal haemodynamics, non-invasive cardiac output monitor, pregnancy, reference range |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10065755 |
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