Efthimiou, N;
Emond, E;
Wadhwa, P;
Cawthorne, C;
Tsoumpas, C;
Thielemans, K;
(2019)
Implementation and validation of time-of-flight PET image reconstruction module for listmode and sinogram projection data in the STIR library.
Physics in Medicine & Biology
10.1088/1361-6560/aaf9b9.
(In press).
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Abstract
In this paper, we describe the implementation of support for Time-of-Flight (TOF) Positron Emission Tomography (PET) for both listmode and sinogram data in the open source Software for Tomographic Image Reconstruction (STIR). We provide validation and performance characterization using simulated data from the open source GATE Monte Carlo toolbox, with TOF configurations spanning from 81.2 to 209.6 ps. The coincidence detector resolution was corrected for the timing resolution deterioration due to the contribution of the crystal length. Comparison between the reconstruction of listmode and sinogram data demonstrated good agreement in both TOF and non-TOF cases in terms of relative absolute error. To reduce the reconstruction time, we assessed the truncation of the TOF kernel along Lines-of-Response (LOR). Rejection of LOR elements beyond four times the TOF standard deviation provides significant acceleration of ≈45% without compromising the image quality. Further narrowing of the kernel can provide extra time reduction but with the gradual introduction of error in the reconstructed images. As expected, TOF reconstruction performs better than non-TOF in terms of both Contrast-Recovery-Coefficient (CRC) and Signal-to-Noise ratio (SNR). CRC achieves convergence faster with TOF, at lower noise levels. SNR with TOF was superior for early iterations, but with quick deterioration. Higher timing resolution further improved reconstruction performance, while TOF bin mashing was shown to have only a small impact on reconstructed images.
| Type: | Article |
|---|---|
| Title: | Implementation and validation of time-of-flight PET image reconstruction module for listmode and sinogram projection data in the STIR library |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1088/1361-6560/aaf9b9 |
| Publisher version: | https://doi.org/10.1088/1361-6560/aaf9b9 |
| Language: | English |
| Additional information: | As the Version of Record of this article is going to be/has been published on a gold open access basis under a CC BY 3.0 licence (https://creativecommons.org/licenses/by/3.0/), this Accepted Manuscript is available for reuse under a CC BY 3.0 licence immediately |
| Keywords: | Computer Simulations, Medical Imaging, Monte Carlo, Open-source software, Positron Emission Tomography, Radionuclide Imaging, Time-of-Flight |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10065518 |
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