Poisnel, G;
Arenaza-Urquijo, E;
Collette, F;
Klimecki, OM;
Marchant, NL;
Wirth, M;
de La Sayette, V;
... Medit-Ageing Research Group, .; + view all
(2018)
The Age-Well randomized controlled trial of the Medit-Ageing European project: Effect of meditation or foreign language training on brain and mental health in older adults.
Alzheimer's & Dementia: Translational Research & Clinical Interventions
, 4
pp. 714-723.
10.1016/j.trci.2018.10.011.
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Abstract
INTRODUCTION: The Age-Well clinical trial is an ongoing monocentric, randomized, controlled trial aiming to assess an 18-month preventive meditation-based intervention directly targeting the attentional and emotional dimensions of aging to promote mental health and well-being in elderly people. METHODS: One hundred thirty-seven cognitively unimpaired older adults are randomized to either an 18-month meditation-based intervention, a structurally matched foreign language training, or a passive control arm. The impact of the intervention and underlying mechanisms are assessed with detailed cognitive, behavioral, biological, neuroimaging and sleep examinations. RESULTS: Recruitment began in late 2016 and ended in May 2018. The interventions are ongoing and will be completed by early 2020. DISCUSSION: This is the first trial addressing the emotional and cognitive dimension of aging with a long-term nonpharmacological approach and using comprehensive assessments to investigate the mechanisms. Results are expected to foster the development of preventive strategies reducing the negative impact of mental conditions and disorders.
| Type: | Article |
|---|---|
| Title: | The Age-Well randomized controlled trial of the Medit-Ageing European project: Effect of meditation or foreign language training on brain and mental health in older adults |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.trci.2018.10.011 |
| Publisher version: | https://doi.org/10.1016/j.trci.2018.10.011 |
| Language: | English |
| Additional information: | © 2018 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Aging, Alzheimer's disease, Attention, Blood markers, Cognition, Compassion, Dementia, Emotion, Foreign language training, Lifestyle, Meditation, Mindfulness, Neuroimaging, Prevention, Reserve, Sleep |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10065254 |
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