McCarthy, S;
Das, S;
Kretzschmar, W;
Delaneau, O;
Wood, AR;
Teumer, A;
Kang, HM;
... Marchini, J; + view all
(2016)
A reference panel of 64,976 haplotypes for genotype imputation.
[Letter].
Nature Genetics
, 48
(10)
pp. 1279-1283.
10.1038/ng.3643.
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Abstract
We describe a reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry. Using this resource leads to accurate genotype imputation at minor allele frequencies as low as 0.1% and a large increase in the number of SNPs tested in association studies, and it can help to discover and refine causal loci. We describe remote server resources that allow researchers to carry out imputation and phasing consistently and efficiently.
| Type: | Article |
|---|---|
| Title: | A reference panel of 64,976 haplotypes for genotype imputation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/ng.3643 |
| Publisher version: | https://doi.org/10.1038/ng.3643 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Genome-wide association studies, Population genetics |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10064548 |
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