Askew, K;
Li, K;
Olmos-Alonso, A;
Garcia-Moreno, F;
Liang, Y;
Richardson, P;
Tipton, T;
... Gomez-Nicola, D; + view all
(2017)
Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain.
Cell Reports
, 18
(2)
pp. 391-405.
10.1016/j.celrep.2016.12.041.
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Abstract
Microglia play key roles in brain development, homeostasis, and function, and it is widely assumed that the adult population is long lived and maintained by self-renewal. However, the precise temporal and spatial dynamics of the microglial population are unknown. We show in mice and humans that the turnover of microglia is remarkably fast, allowing the whole population to be renewed several times during a lifetime. The number of microglial cells remains steady from late postnatal stages until aging and is maintained by the spatial and temporal coupling of proliferation and apoptosis, as shown by pulse-chase studies, chronic in vivo imaging of microglia, and the use of mouse models of dysregulated apoptosis. Our results reveal that the microglial population is constantly and rapidly remodeled, expanding our understanding of its role in the maintenance of brain homeostasis.
| Type: | Article |
|---|---|
| Title: | Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.celrep.2016.12.041 |
| Publisher version: | https://doi.org/10.1016/j.celrep.2016.12.041 |
| Language: | English |
| Additional information: | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | self-renewal, BrdU, CSF1R, CX3CR1, Macgreen, Vav-Bcl2RNA-seq |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UK Dementia Research Institute HQ |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10064129 |
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