Minlikeeva, AN;
Freudenheim, JL;
Cannioto, RA;
Eng, KH;
Szender, JB;
Mayor, P;
Etter, JL;
... Moysich, KB; + view all
(2017)
History of thyroid disease and survival of ovarian cancer patients: results from the Ovarian Cancer Association Consortium, a brief report.
British Journal of Cancer
, 117
(7)
pp. 1063-1069.
10.1038/bjc.2017.267.
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Abstract
BACKGROUND: Findings from in vitro studies suggest that increased exposure to thyroid hormones can influence progression of ovarian tumours. However, epidemiologic evidence on this topic is limited. METHODS: We pooled data from 11 studies from the Ovarian Cancer Association Consortium. Using multivariate Cox proportional hazards models, we estimated associations between hyper- and hypothyroidism and medications prescribed for these conditions with 5-year all-cause survival among women diagnosed with invasive ovarian cancer. RESULTS: Overall, there was a nonsignificant association with history of hyperthyroidism (n=160 cases) and mortality (HR=1.22; 95% CI=0.97-1.53). Furthermore, diagnosis of hyperthyroidism within the 5 years before ovarian cancer diagnosis was associated with an increased risk of death (HR=1.94; 95% CI=1.19-3.18). A more modest association was observed with history of hypothyroidism (n=624 cases) and mortality (HR=1.16; 95% CI=1.03-1.31). Neither duration of hypothyroidism nor use of thyroid medications was associated with survival. CONCLUSIONS: In this large study of women with ovarian cancer, we found that recent history of hyperthyroidism and overall history of hypothyroidism were associated with worse 5-year survival.
| Type: | Article |
|---|---|
| Title: | History of thyroid disease and survival of ovarian cancer patients: results from the Ovarian Cancer Association Consortium, a brief report |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/bjc.2017.267 |
| Publisher version: | http://doi.org/10.1038/bjc.2017.267 |
| Language: | English |
| Additional information: | This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons AttributionNonCommercial-Share Alike 4.0 Unported License. |
| Keywords: | Aged, Female, Humans, Hyperthyroidism, Hypothyroidism, Middle Aged, Ovarian Neoplasms, Proportional Hazards Models, Survival Rate, Time Factors |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10064021 |
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