Serfaty, M;
Armstrong, M;
Vickerstaff, V;
Davis, S;
Gola, A;
McNamee, P;
Omar, RZ;
... Low, JTS; + view all
(2019)
Acceptance and commitment therapy for adults with advanced cancer (CanACT): A feasibility randomised controlled trial.
Psycho-Oncology
, 28
(3)
pp. 488-496.
10.1002/pon.4960.
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Abstract
OBJECTIVE: To understand the feasibility of recruiting people with advanced cancer into a randomised controlled trial of Acceptance and Commitment therapy (ACT) vs a standardised Talking Control (TC) and delivering ACT to this population; to explore the acceptability of outcome measures and generate normative data. METHODS: This was a feasibility two-arm randomised controlled trial. Participants were attendees with advanced cancer at one of three hospice-based day- therapy units in London, UK, who demonstrated low scores on the Functional Assessment of Cancer Therapies - General (FACT-G). The primary end point was three months. RESULTS: The recruitment target was 54 participants; 42 people were recruited and randomised to up to eight individual sessions of ACT (n=20) or TC (n=22). 18/42 (43%) of participants completed the primary outcome at three months, and at least one follow-up was available in 30/42 (71%) participants. An exploratory analysis revealed a non-significant adjusted mean difference after three months in the main outcome FACT-G of -3.41 (CI= -18.61, 11.79) with TC having better functioning. Over six months the adjusted mean difference between trial arms was 2.25 (CI= -6.03, 10.52) in favour of ACT. CONCLUSIONS: It is feasible to recruit people with advanced cancer in a trial of ACT versus TC. Future research should test the effectiveness of ACT in a fully powered trial.
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