Ghoreishizadeh, SS;
Taurino, I;
De Micheli, G;
Carrara, S;
Georgiou, P;
(2017)
A Differential Electrochemical Readout ASIC With Heterogeneous Integration of Bio-Nano Sensors for Amperometric Sensing.
IEEE Transactions on Biomedical Circuits and Systems
, 11
(5)
pp. 1148-1159.
10.1109/TBCAS.2017.2733624.
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Abstract
A monolithic biosensing platform is presented for miniaturized amperometric electrochemical sensing in CMOS. The system consists of a fully integrated current readout circuit for differential current measurement as well as on-die sensors developed by growing platinum nanostructures (Pt-nanoS) on top of electrodes implemented with the top metal layer. The circuit is based on the switch-capacitor technique and includes pseudodifferential integrators for concurrent sampling of the differential sensor currents. The circuit further includes a differential to single converter and a programmable gain amplifier prior to an ADC. The system is fabricated in 0.35 μm technology and measures current within ±20 μA with minimum input-referred noise of 0.47 pA and consumes 9.3 mW from a 3.3 V supply. Differential sensing for nanostructured sensors is proposed to build highly sensitive and offsetfree sensors for metabolite detection. This is successfully tested for bio-nano-sensors for the measurement of glucose in submilli molar concentrations with the proposed readout IC. The on-die electrodes are nanostructured and cyclic voltammetry run successfully through the readout IC to demonstrate detection of H2 O2.
| Type: | Article |
|---|---|
| Title: | A Differential Electrochemical Readout ASIC With Heterogeneous Integration of Bio-Nano Sensors for Amperometric Sensing |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1109/TBCAS.2017.2733624 |
| Publisher version: | https://doi.org/10.1109/TBCAS.2017.2733624 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Current measurement, Clocks, Biosensors, Multiplexing, Biomedical measurement, Sugar |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Electronic and Electrical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10063265 |
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