Malandrino, A; Moeendarbary, E; (2019) Poroelasticity of Living Tissues. In: Narayan, R, (ed.) Encyclopedia of Biomedical Engineering. (pp. 238-245). Elsevier: Amsterdam, Netherlands.

Text Poroelasticity of living tissues-SUB_R2.docx - Accepted Version Access restricted to UCL open access staff Download (215kB)

Abstract

Nature presents to us a plethora of materials composed by mixtures of finely assembled phases, the most abundant in biology being the fluid phase that mainly comprises of water. Physical interactions of water with other phases are fundamental to describe many systems, including living materials. The theory of poroelasticity provides a way to describe the mechanical behavior resulting from these hydraulic effects, by modeling a porous medium consisting of an elastic solid skeleton infiltrated by fluid-saturated interlinked pores. This powerful approach can relate microstructural parameters, phases, and interactions, to scaled-up continuum mechanical properties measurable with experiments. Following presentation of basic poroelastic equations, we present how this theoretical framework is relevant for robust mechanical modeling of tissues and cells, providing compositional and structural idealizations to characterize viscoelastic responses via realistic, physical, and measurable parameters.

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