Desai, M;
Mohamed, A;
Davenport, A;
(2019)
A pilot study investigating the effect of pedalling exercise during dialysis on six-minute walking test and hand grip and pinch strength.
The International Journal of Artificial Organs
, 42
(4)
pp. 161-166.
10.1177/0391398818823761.
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Abstract
INTRODUCTION: Haemodialysis (HD) patients are at increased risk of sarcopenia. Physical inactivity is now recognised as a major cause of muscle wasting in HD patients. It is unclear as to what exercise and how much exercise is required to show benefit. We therefore performed a pilot study of cycling during HD. // METHODS: Patients underwent a progressive submaximal individualised cycling-exercise, 3 x week during HD for 4 months using bed-cycle ergometers. Body composition was measured by multifrequency segmental bioimpedance and muscle function by 6-minute walking test (6MWT), and hand grip (HGS) and pinch strength (PS). // RESULTS: 56% of patients in a dialysis centre fulfilled exercise study inclusion criteria, and 13 (72.2%) of 18 patients completed the exercise program, mean age 64.0±16.6 years, 76.9% male. 6MWT increased following exercise from 349±105 to 398±94.2 m, p<0.05, as did both HGS and PS; 20.4±9.1 vs 23.4±9.9 kg, p<0.01 and 4.3±1.8 vs 5.9±2.4 kg, p<0.05, respectively. There were no changes in appendicular muscle mass, or other body composition detected with bioimpedance in either the exercise group, or 21 control patients, propensity matched for body composition, co-morbidity and frailty. Muscle strength did not change in the control group. HD sessional Kt/Vurea was greater at the end of the exercise program compared to controls; 1.63±0.63 vs 1.21±0.12, p<0.01. // CONCLUSIONS: The majority of dialysis centre patients met our exercise study entry criteria and could potentially benefit from cycling during HD. We found that muscle function and strength improved after a four month, thrice weekly cycling exercise program.
| Type: | Article |
|---|---|
| Title: | A pilot study investigating the effect of pedalling exercise during dialysis on six-minute walking test and hand grip and pinch strength |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/0391398818823761 |
| Publisher version: | https://doi.org/10.1177/0391398818823761 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10062679 |
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