Toorell, H;
Zetterberg, H;
Blennow, K;
Savman, K;
Hagberg, H;
(2018)
Increase of neuronal injury markers Tau and neurofilament light proteins in umbilical blood after intrapartum asphyxia.
The Journal of Maternal-Fetal & Neonatal Medicine
, 31
(18)
pp. 2468-2472.
10.1080/14767058.2017.1344964.
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Abstract
Aim: Compare the levels of the brain injury biomarkers Tau and neurofilament light protein (NFL) in cases of asphyxia with those in controls. Materials and methods: We analyzed the neuronal proteins Tau and NFL in umbilical blood of 10 cases of severe-moderate intrapartum asphyxia and in 18 control cases. Results: The levels of both Tau and neurofilament were significantly higher after asphyxia and it appeared to be a correlation between the levels of the biomarkers and the severity of the insult. Discussion: Future studies are warranted to support or refute the value of Tau/NFLin clinical practice. Conclusion: Fetal asphyxia remains a clinical problem resulting in life-long neurological disabilities. We urgently need more accurate early predictive markers to direct the clinician when to provide neuroprotective therapy.
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