van der Hoorn, A;
Yan, J-L;
Larkin, TJ;
Boonzaier, NR;
Matys, T;
Price, SJ;
(2016)
Posttreatment Apparent Diffusion Coefficient Changes in the Periresectional Area in Patients with Glioblastoma.
World Neurosurgery
, 92
pp. 159-165.
10.1016/j.wneu.2016.04.129.
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Abstract
BACKGROUND: Although targeted by radiotherapy, recurrence in glioblastoma occurs mainly periresectionally owing to tumor infiltration. An increase in the apparent diffusion coefficient (ADC) has been shown in the large high-T2 area on magnetic resonance imaging posttreatment; however, until now ADC has not been investigated directly in the more relevant periresectional area. METHODS: Histogram analysis was used to assess periresectional ADC values in patients with glioblastoma postradiotherapy versus preradiotherapy. Periresectional ADC values starting at 0–5 mm in 5-mm increments up to 20–25 mm were extracted and compared using 2-way repeated-measurements analysis of variance. RESULTS: Mean ADC values directly adjacent to the resection area (0–5 mm) were significantly higher postradiotherapy compared with preradiotherapy (P = .017). ADC values in the 0- to 5-mm region were also higher than those in 5- to 10-, 10- to 15-, and 15- to 20-mm regions (P < .05). Regional standard deviations in ADC values were higher postradiotherapy compared with preradiotherapy for the 0- to 5-mm region up to the 15- to 20-mm region, inclusive (P < .05); however, Cox regression analysis showed no survival benefits from the increased ADC in the 0- to 5-mm region postradiotherapy. CONCLUSIONS: Increased ADC values, representing a decrease in infiltrative tumor load, were demonstrated in a limited direct periresectional area. This finding adds to previous studies evaluating ADC response in the larger high-T2 area in relation to survival.
| Type: | Article |
|---|---|
| Title: | Posttreatment Apparent Diffusion Coefficient Changes in the Periresectional Area in Patients with Glioblastoma |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.wneu.2016.04.129 |
| Publisher version: | https://doi.org/10.1016/j.wneu.2016.04.129 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Apparent diffusion coefficient, Brain tumor, Glioblastoma, Magnetic resonance imaging, Treatment response |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10060129 |
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