Cross, JH;
Spoudeas, H;
(2017)
Medical management and antiepileptic drugs in hypothalamic hamartoma.
Epilepsia
, 58
(S2)
pp. 16-21.
10.1111/epi.13758.
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Abstract
Hypothalamic hamartoma may present with epilepsy, specifically gelastic or dacrystic seizures, or endocrine dysfunction, commonly precocious puberty. The epilepsy in many patients is drug resistant, and has a high association with progressive cognitive, learning and behavioral difficulty. Medical treatment of seizures remains problematic, with many resistant to drug treatment. Surgical resection, or disconnection of the hamartoma provides the optimal chance of seizure control but with a relatively high risk of endocrine dysfunction, the result of interference with the hypothalamic‐pituitary axis in many. Careful assessment and monitoring by specialist centers with discussion of optimal intervention is required for individual cases.
| Type: | Article |
|---|---|
| Title: | Medical management and antiepileptic drugs in hypothalamic hamartoma |
| Event: | 2nd International Hypothalmic Hamartomas Symposium |
| Location: | Marseille, FRANCE |
| Dates: | September 2013 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/epi.13758 |
| Publisher version: | https://doi.org/10.1111/epi.13758 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Hypothalamic hamartoma, Epilepsy, Gelastic seizures, Antiepileptic drugs, Ketogenic diet |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10059086 |
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