Panicker, JN;
Anding, R;
Arlandis, S;
Blok, B;
Dorrepaal, C;
Harding, C;
Marcelissen, T;
... Apostolidis, A; + view all
(2018)
Do we understand voiding dysfunction in women? Current understanding and future perspectives: ICI-RS 2017.
Neurourology and Urodynamics
, 37
(S4)
S75-S85.
10.1002/nau.23709.
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Abstract
AIMS: Urinary retention in women is poorly understood, compared to the equivalent condition in men, and was the subject of a dedicated session organized at the International Consultation on Incontinence Research Society (ICI‐RS) in Bristol, United Kingdom, 2017. METHODS: The current understanding of the pathophysiological correlates of idiopathic voiding dysfunction in women, the role of urodynamics, neurophysiology, and non‐invasive tests in characterizing functional bladder outlet obstruction due to a non‐relaxing urethral sphincter, and poorly defined diagnosis of detrusor underactivity were reviewed. RESULTS: Putative factors underlying the pathogenesis of urinary retention following urinary tract infections were discussed. Further research is required to explore the association between bladder wall inflammation and alterations in detrusor contractile functions. The complex interrelationship between urinary retention and psychological co‐morbidities and sexual trauma were explored, and the overlap between these and psychological co‐morbidities and functional neurological problems with functional urological problems were recognized. Understanding the mechanism of action of sacral neuromodulation, often a successful treatment for urinary retention, would provide insight into the underlying factors that may be responsible for urinary retention. Specifically, there is a need to understand the role of the endogenous enkephalinergic system in the pathogenesis of urinary retention and to identify predictors of successful treatment with sacral neuromodulation. Based on current understanding and potential directions of research in the future, an algorithm for the evaluation of women with voiding dysfunction was proposed. CONCLUSIONS: In the future, recommendations for research should lead to a better understanding of urinary retention in women and its treatment.
| Type: | Article |
|---|---|
| Title: | Do we understand voiding dysfunction in women? Current understanding and future perspectives: ICI-RS 2017 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/nau.23709 |
| Publisher version: | http://dx.doi.org/10.1002/nau.23709 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Urology & Nephrology, dysfunctional voiding, Fowler's syndrome, opiates, psychological co-morbidities, sacral neuromodulation, sexual abuse, urinary tract infections, voiding dysfunction, URINARY-TRACT SYMPTOMS, BLADDER OUTLET OBSTRUCTION, SACRAL NEUROMODULATION TREATMENT, COMPLEX REPETITIVE DISCHARGES, SEXUAL-ABUSE HISTORY, FEMALE PELVIC FLOOR, DETRUSOR UNDERACTIVITY, FOWLERS-SYNDROME, 3-DIMENSIONAL ULTRASOUND, URETHRAL SPHINCTER |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10058342 |
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