Nommiste, B;
Fynes, K;
Tovell, VE;
Ramsden, C;
da Cruz, L;
Coffey, P;
(2017)
Stem cell-derived retinal pigment epithelium transplantation for treatment of retinal disease.
Progress in Brain Research
, 231
pp. 225-244.
10.1016/bs.pbr.2017.03.003.
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1-s2.0-S0079612317300158-main.pdf - Published Version Access restricted to UCL open access staff Download (1MB) |
Abstract
Age-related macular degeneration remains the most common cause of blindness in the western world, severely comprising patients' and carers' quality of life and presenting a great cost to the healthcare system. As the disease progresses, the retinal pigmented epithelium (RPE) layer at the back of the eye degenerates, contributing to a series of events resulting in visual impairment. The easy accessibility of the eye has allowed for in-depth study of disease progression in patients, while in vivo studies have facilitated investigations into healthy and diseased RPE. Consequently, a number of research groups are examining different approaches for the replacement of RPE cells in age-related macular degeneration (AMD) patients. This chapter examines some of these initial proof-of-principle studies and goes on to review the use of pluripotent stem cells as a source for RPE replacement in a number of current AMD clinical trials. Finally, we consider just some of the regulatory and manufacturing challenges presented in taking a promising AMD treatment from the research bench into clinical trials in patients, and how to mitigate potential risks early in process development.
Type: | Article |
---|---|
Title: | Stem cell-derived retinal pigment epithelium transplantation for treatment of retinal disease |
DOI: | 10.1016/bs.pbr.2017.03.003 |
Publisher version: | https://doi.org/10.1016/bs.pbr.2017.03.003 |
Language: | English |
Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
Keywords: | Retinal pigmented epithelium, Retinal disease, Age-related macular degeneration |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
URI: | https://discovery.ucl.ac.uk/id/eprint/10058065 |
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