Hayes, W;
(2018)
Ab-normal saline in abnormal kidney function: risks and alternatives.
[Review].
Pediatric Nephrology
10.1007/s00467-018-4008-1.
(In press).
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Abstract
Intravenous 0.9% saline has saved countless lives since it was introduced over a century ago. It remains the most widespread crystalloid in both adult and pediatric practice. However, in recent years, evidence of deleterious effects is accruing. These include increased mortality, acute kidney injury (AKI), metabolic acidosis, and coagulopathy. The predominant cause for these sequelae appears to be the excess chloride concentration of 0.9% saline relative to plasma. This has led to development of balanced isotonic solutions such as PlasmaLyte. This review summarizes current evidence for adverse effects of chloride-rich intravenous fluid and considers whether 0.9% saline should still be used in 2018 or abandoned as a historical treatment in favor of balanced crystalloid solutions.
| Type: | Article |
|---|---|
| Title: | Ab-normal saline in abnormal kidney function: risks and alternatives |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s00467-018-4008-1 |
| Publisher version: | https://doi.org/10.1007/s00467-018-4008-1 |
| Language: | English |
| Additional information: | Copyright © the Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| Keywords: | metabolic acidosis, saline solution, water-electrolyte balance, acute kidney injury, chronic kidney disease |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10057461 |
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