Longo, E;
Bravin, A;
Brun, F;
Bukreeva, I;
Cedola, A;
De La Rochefoucauld, O;
Fratini, M;
... Zeitoun, P; + view all
(2018)
3D imaging of theranostic nanoparticles in mice organs by means of x-ray phase contrast tomography.
In: Lo, JY and Schmidt, TG and Chen, GH and Berliner, Leonard and Summers, Ronald M, (eds.)
Proceedings of the SPIE Medical Imaging 2018.
SPIE (Society of Photo-optical Instrumentation Engineers) Publishing: Bellingham, WA, USA.
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Abstract
Theranostics is an innovative research field that aims to develop high target specificity cancer treatments by administering small metal-based nanoparticles (NPs). This new generation of compounds exhibits diagnostic and therapeutic properties due to the high atomic number of their metal component. In the framework of a combined research program on low dose X-ray imaging and theranostic NPs, X-ray Phase Contrast Tomography (XPCT) was performed at ESRF using a 3 µm pixel optical system on two samples: a mouse brain bearing melanoma metastases injected with gadolinium NPs and, a mouse liver injected with gold NPs. XPCT is a non-destructive technique suitable to achieve the 3D reconstruction of a specimen and, widely used at micro-scale to detect abnormalities of the vessels, which are associated to the tumor growth or to the development of neurodegenerative diseases. Moreover, XPCT represents a promising and complementary tool to study the biodistribution of theranostic NPs in biological materials, thanks to the strong contrast with respect to soft tissues that metal-based NPs provide in radiological images. This work is relied on an original imaging approach based on the evaluation of the contrast differences between the images acquired below and above K-edge energies, as a proof of the certain localization of NPs. We will present different methods aiming to enhance the localization of NPs and a 3D map of their distribution in large volume of tissues.
| Type: | Proceedings paper |
|---|---|
| Title: | 3D imaging of theranostic nanoparticles in mice organs by means of x-ray phase contrast tomography |
| Event: | SPIE Medical Imaging 2018, 10-15 February 2018, Houston, Texas, USA |
| Location: | Houston, TX |
| Dates: | 12 February 2018 - 15 February 2018 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1117/12.2293090 |
| Publisher version: | https://doi.org/10.1117/12.2293090 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | nanoparticles; x-ray phase contrast tomography; 3D rendering |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10057111 |
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