Hutter, J;
Slator, P;
Jackson, L;
Dos Santos Gomes, A;
Ho, A;
Story, L;
O'Muircheartaigh, J;
... Hajnal, J; + view all
(2019)
Multi-modal functional MRI to explore placental function over gestation.
Magnetic Resonance in Medicine
, 81
(2)
pp. 1191-1204.
10.1002/mrm.27447.
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Abstract
Purpose: To investigate, visualize and quantify the physiology of the human placenta in several dimensions ‐ functional, temporal over gestation, and spatial over the whole organ. Methods: Bespoke MRI techniques, combining a rich diffusion protocol, anatomical data and T2* mapping together with a multi‐modal pipeline including motion correction and extracted quantitative features were developed and employed on pregnant women between 22 and 38 weeks gestational age including two pregnancies diagnosed with pre‐eclampsia. Results: A multi‐faceted assessment was demonstrated showing trends of increasing lacunarity, and decreasing T2* and diffusivity over gestation. Conclusions: The obtained multi‐modal acquisition and quantification shows promising opportunities for studying evolution, adaptation and compensation processes.
| Type: | Article |
|---|---|
| Title: | Multi-modal functional MRI to explore placental function over gestation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/mrm.27447 |
| Publisher version: | https://doi.org/10.1002/mrm.27447 |
| Language: | English |
| Additional information: | Copyright © 2018 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | placenta, diffusion MRI, relaxometry, development, pregnancy complications, postprocessing |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10056893 |
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