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c302: a multiscale framework for modelling the nervous system of Caenorhabditis elegans

Gleeson, P; Lung, D; Grosu, R; Hasani, R; Larson, SD; (2018) c302: a multiscale framework for modelling the nervous system of Caenorhabditis elegans. Philosophical Transactions of The Royal Society B: Biological Sciences , 373 (1758) , Article 20170380. 10.1098/rstb.2017.0379. Green open access

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Abstract

The OpenWorm project has the ambitious goal of producing a highly detailed in silico model of the nematode Caenorhabditis elegans A crucial part of this work will be a model of the nervous system encompassing all known cell types and connections. The appropriate level of biophysical detail required in the neuronal model to reproduce observed high-level behaviours in the worm has yet to be determined. For this reason, we have developed a framework, c302, that allows different instances of neuronal networks to be generated incorporating varying levels of anatomical and physiological detail, which can be investigated and refined independently or linked to other tools developed in the OpenWorm modelling toolchain.This article is part of a discussion meeting issue 'Connectome to behaviour: modelling C. elegans at cellular resolution'.

Type: Article
Title: c302: a multiscale framework for modelling the nervous system of Caenorhabditis elegans
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1098/rstb.2017.0379
Publisher version: https://doi.org/10.1098/rstb.2017.0379
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: C. elegans, computational neuroscience, open source, simulation, standardization
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/10056647
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