Garg, K;
Ghosh, M;
Eliash, T;
van Wonderen, JH;
Butt, JN;
Shi, L;
Jiang, X;
... Cahen, D; + view all
(2018)
Direct evidence for heme-assisted solid-state electronic conduction in multi-heme c-type cytochromes.
Chemical Science
, 9
(37)
pp. 7304-7310.
10.1039/C8SC01716F.
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Abstract
Multi-heme cytochrome c (Cytc) proteins are key for transferring electrons out of cells, to enable intracellular oxidation to proceed in the absence of O2. In these proteins most of the hemes are arranged in a linear array suggesting a facile path for electronic conduction. To test this, we studied solvent-free electron transport across two multi-heme Cytc-type proteins: MtrF (deca-heme Cytc) and STC (tetra-heme Cytc). Transport is measured across monolayers of these proteins in a solid state configuration between Au electrodes. Both proteins showed 1000× higher conductance than single heme, or heme-free proteins, but similar conductance to monolayers of conjugated organics. Conductance is found to be temperature-independent (320–80 K), suggesting tunneling as the transport mechanism. This mechanism is consistent with I–V curves modelling, results of which could be interpreted by having protein-electrode coupling as rate limiting, rather than transport within the proteins.
| Type: | Article |
|---|---|
| Title: | Direct evidence for heme-assisted solid-state electronic conduction in multi-heme c-type cytochromes |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/C8SC01716F |
| Publisher version: | http://dx.doi.org/10.1039/C8SC01716F |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10055772 |
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