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Direct evidence for heme-assisted solid-state electronic conduction in multi-heme c-type cytochromes

Garg, K; Ghosh, M; Eliash, T; van Wonderen, JH; Butt, JN; Shi, L; Jiang, X; ... Cahen, D; + view all (2018) Direct evidence for heme-assisted solid-state electronic conduction in multi-heme c-type cytochromes. Chemical Science , 9 (37) pp. 7304-7310. 10.1039/C8SC01716F. Green open access

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Abstract

Multi-heme cytochrome c (Cytc) proteins are key for transferring electrons out of cells, to enable intracellular oxidation to proceed in the absence of O2. In these proteins most of the hemes are arranged in a linear array suggesting a facile path for electronic conduction. To test this, we studied solvent-free electron transport across two multi-heme Cytc-type proteins: MtrF (deca-heme Cytc) and STC (tetra-heme Cytc). Transport is measured across monolayers of these proteins in a solid state configuration between Au electrodes. Both proteins showed 1000× higher conductance than single heme, or heme-free proteins, but similar conductance to monolayers of conjugated organics. Conductance is found to be temperature-independent (320–80 K), suggesting tunneling as the transport mechanism. This mechanism is consistent with I–V curves modelling, results of which could be interpreted by having protein-electrode coupling as rate limiting, rather than transport within the proteins.

Type: Article
Title: Direct evidence for heme-assisted solid-state electronic conduction in multi-heme c-type cytochromes
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/C8SC01716F
Publisher version: http://dx.doi.org/10.1039/C8SC01716F
Language: English
Additional information: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy
URI: https://discovery.ucl.ac.uk/id/eprint/10055772
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