Daniel, MC;
Dubis, AM;
Theodorou, M;
Quartilho, A;
Adams, G;
Brookes, J;
Papadopoulos, M;
... Dahlmann-Noor, AH; + view all
(2018)
Childhood lensectomy is associated with static and dynamic reduction in Schlemm canal size: a biomechanical hypothesis of post-lensectomy glaucoma.
Ophthalmology
10.1016/j.ophtha.2018.08.031.
(In press).
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Abstract
OBJECTIVE: To compare Schlemm canal (SC) and trabecular meshwork (TM) in children with healthy eyes and those with and without glaucoma after lensectomy. DESIGN: Cross-sectional observational study. PARTICIPANTS: Fifty children age 4 to 16 years with healthy eyes and 48 children post lensectomy (124 healthy and 72 post-lensectomy eyes). METHODS: /Interventions: Anterior segment optical coherence tomography (AS-OCT, Tomey Casia) of the nasal iridocorneal angle, at two levels of accommodative effort (2.5D, 15D). For each parameter and state of accommodation, a random-effects model was fitted to estimate differences between healthy eyes and eyes with history of lensectomy. MAIN OUTCOME MEASURES: Dimensions of SC and TM; conventional AS-OCT irido-corneal angle (ICA) measurements. RESULTS: The horizontal diameter of SC and its cross-sectional area (SC-CSA) are significantly smaller in post-lensectomy than in healthy eyes. Accommodative effort increases SC size in healthy, but not in post-lensectomy eyes. CONCLUSIONS: Lensectomy is associated with a reduction in SC size and a loss of physiological SC dilatation during accommodative effort, which may reflect a reduction in outflow facility and contribute to the development of post-lensectomy glaucoma.
| Type: | Article |
|---|---|
| Title: | Childhood lensectomy is associated with static and dynamic reduction in Schlemm canal size: a biomechanical hypothesis of post-lensectomy glaucoma |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ophtha.2018.08.031 |
| Publisher version: | https://doi.org/10.1016/j.ophtha.2018.08.031 |
| Language: | English |
| Additional information: | © 2018 Published by Elsevier Inc. on behalf of the American Academy of Ophthalmology. This is an Open Access article distributed under the terms of the Creative Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Child, Adolescent, Congenital, Hereditary and Neonatal Diseases and Abnormalities, Cataract, Glaucoma |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10055736 |
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