Segal, AW;
(2018)
The role of neutrophils in the pathogenesis of Crohn's disease.
European Journal of Clinical Investigation
10.1111/eci.12983.
(In press).
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Abstract
Crohn's disease (CD) is caused by a trigger, almost certainly enteric infection by one of a multitude of organisms that allows faeces access to the tissues, at which stage the response of individuals predisposed to CD is abnormal. In CD the failure of acute inflammation results in the failure to recruit neutrophils to the inflammatory site, as a consequence of which the clearance of bacteria from the tissues is defective. The retained faecal products result in the characteristic chronic granulomatous inflammation and adaptive immune response. Impaired of digestion of bacteria and fungi by CGD neutrophils can result in a similar pathological and clinical picture. The neutrophils in CD are normal and their inadequate accumulation at sites of inflammation generally results from diminished secretion of pro-inflammatory cytokines by macrophages consequent upon disordered vesicle trafficking. This article is protected by copyright. All rights reserved.
| Type: | Article |
|---|---|
| Title: | The role of neutrophils in the pathogenesis of Crohn's disease |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/eci.12983 |
| Publisher version: | http://dx.doi.org/10.1111/eci.12983 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | CGD, Bacteria, Crohn's, Gastroenteritis, Immunology, Infection, Inflammatory Bowel Disease |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10055630 |
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