Khilkevich, A;
Canton-Josh, J;
DeLord, E;
Mauk, MD;
(2018)
A cerebellar adaptation to uncertain inputs.
Science Advances
, 4
(5)
, Article eaap9660. 10.1126/sciadv.aap9660.
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Abstract
Noise and variability are inherent and unavoidable features of neural processing. Despite this physiological challenge, brain systems function well, suggesting the existence of adaptations that cope with noise. We report a novel adaptation that the cerebellum implements to maintain correct responses in the face of ambiguous inputs. We found that under these conditions, the cerebellum used a probabilistic binary choice: Although the probability of behavioral response gradually increased or decreased depending on the degree of similarity between current and trained inputs, the size of response remained constant. That way the cerebellum kept responses adaptive to trained input corrupted by noise while minimizing false responses to novel stimuli. Recordings and analysis of Purkinje cells activity showed that the binary choice is made in the cerebellar cortex. Results from large-scale simulation suggest that internal feedback from cerebellar nucleus back to cerebellar cortex plays a critical role in implementation of binary choice.
| Type: | Article |
|---|---|
| Title: | A cerebellar adaptation to uncertain inputs |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1126/sciadv.aap9660 |
| Publisher version: | https://doi.org/10.1126/sciadv.aap9660 |
| Language: | English |
| Additional information: | Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10055317 |
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