Orme, T;
Guerreiro, R;
Bras, J;
(2018)
The Genetics of Dementia with Lewy Bodies: Current Understanding and Future Directions.
Current Neurology and Neuroscience Reports
, 18
(10)
, Article 67. 10.1007/s11910-018-0874-y.
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Abstract
PURPOSE OF REVIEW: Dementia with Lewy bodies (DLB) is a neurodegenerative disease that can be clinically and pathologically similar to Parkinson’s disease (PD) and Alzheimer’s disease (AD). Current understanding of DLB genetics is insufficient and has been limited by sample size and difficulty in diagnosis. The first genome-wide association study (GWAS) in DLB was performed in 2017; a time at which the post-GWAS era has been reached in many diseases. RECENT FINDINGS: DLB shares risk loci with AD, in the APOE E4 allele, and with PD, in variation at GBA and SNCA. Interestingly, the GWAS suggested that DLB may also have genetic risk factors that are distinct from those in AD and PD. SUMMARY: Although off to a slow start, recent studies have reinvigorated the field of DLB genetics and these results enable us to start to have a more complete understanding of the genetic architecture of this disease.
| Type: | Article |
|---|---|
| Title: | The Genetics of Dementia with Lewy Bodies: Current Understanding and Future Directions |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s11910-018-0874-y |
| Publisher version: | http://doi.org/10.1007/s11910-018-0874-y |
| Language: | English |
| Additional information: | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences, Neurosciences & Neurology, Dementia with Lewy bodies, DLB, Genetics, GWAS, Next-generation sequencing, Genome-Wide Association, Alpha-Synuclein Gene, Familial Parkinsons-Disease, Beta-Glucocerebrosidase Activity, Alzheimers-Disease, Apolipoprotein-E, Body Disease, Frontotemporal Dementia, Locus Triplication, Gaucher-Disease |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10055017 |
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