Mulder, BA;
Geelhoed, B;
van der Harst, P;
Spronk, HM;
Van Gelder, IC;
Asselbergs, FW;
Rienstra, M;
(2018)
Plasminogen activator inhibitor-1 and tissue plasminogen activator and incident AF: Data from the PREVEND study.
International Journal of Cardiology
, 272
pp. 208-210.
10.1016/j.ijcard.2018.08.029.
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Abstract
BACKGROUND: Tissue-type plasminogen activator (TPA) and plasminogen activator inhibitor-1 (PAI-1) have been shown to be associated with increased risk for stroke, however, the association with incident atrial fibrillation (AF) is unknown. METHODS: We examined 8265 individuals included in the PREVEND study. In all subjects, PAI-1 and TPA plasma/serum levels were measured using an ELISA kit. By means of univariate and multivariate analyses the association with incident AF was assessed. RESULTS: Mean age was age 49 ± 13 years, and 50% were women. Of the 8265 patients free of AF at baseline, 267 (3.2%) patients developed incident AF during a mean follow-up of 9.7 ± 2.4 years. Baseline median levels of PAI-1 and TPA were 72.4 ng/ml and 3.1 ng/ml, respectively. In univariate analyses PAI-1 (Hazard ratio [HR] 1.10 95% Confidence interval [CI] 1.04–1.16, p < 0.001) and TPA (HR 1.05, 95% CI 1.01–1.08, p = 0.014) were associated with incident AF. However, after multivariate adjustment for age, sex, antihypertensive drugs, stroke, heart failure, myocardial infarction, diabetes mellitus, peripheral arterial disease, smoking, NT-proBNP, alcohol consumption, body mass index no significant association was found. CONCLUSION: In this community-based cohort, PAI-1 and TPA levels were not associated with incident AF.
| Type: | Article |
|---|---|
| Title: | Plasminogen activator inhibitor-1 and tissue plasminogen activator and incident AF: Data from the PREVEND study |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ijcard.2018.08.029 |
| Publisher version: | https://doi.org/10.1016/j.ijcard.2018.08.029 |
| Language: | English |
| Additional information: | © 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | PAI-1, TPA, Atrial fibrillation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10055001 |
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