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Synthetic Biology and Engineered Live Biotherapeutics: Toward Increasing System Complexity

Ozdemir, T; Fedorec, AJH; Danino, T; Barnes, CP; (2018) Synthetic Biology and Engineered Live Biotherapeutics: Toward Increasing System Complexity. Cell Systems , 7 (1) pp. 5-16. 10.1016/j.cels.2018.06.008. Green open access

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Abstract

Recent advances in synthetic biology and biological system engineering have allowed the design and construction of engineered live biotherapeutics targeting a range of human clinical applications. In this review, we outline how systems approaches have been used to move from simple constitutive systems, where a single therapeutic molecule is expressed, to systems that incorporate sensing of the in vivo environment, feedback, computation, and biocontainment. We outline examples where each of these capabilities are achieved in different human disorders, including cancer, inflammation, and metabolic disease, in a number of environments, including the gastrointestinal tract, the liver, and the oral cavity. Throughout, we highlight the challenges of developing microbial therapeutics that are both sensitive and specific. Finally, we discuss how these systems are leading to the realization of engineered live biotherapeutics in the clinic.

Type: Article
Title: Synthetic Biology and Engineered Live Biotherapeutics: Toward Increasing System Complexity
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cels.2018.06.008
Publisher version: http://doi.org/10.1016/j.cels.2018.06.008
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: bioengineering, drug delivery, engineered probiotics, live biotherapeutics, microbiome, synthetic biology
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10053831
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