Pilavaki, E;
Valente, V;
Demosthenous, A;
(2018)
CMOS Image Sensor for Lateral Flow Immunoassay Readers.
IEEE Transactions on Circuits and Systems II: Express Briefs
, 65
(10)
pp. 1405-1409.
10.1109/TCSII.2018.2855054.
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Abstract
Point-of-care systems for the detection of infectious diseases are in great demand especially in developing countries. Lateral flow immunoassays are considered ideal biosensors for point-of-care diagnostics due to their numerous advantages. However, to quantify their results a low power, robust electronic reader is needed. A low power CMOS image sensor is presented that can be used in quantitative lateral flow immunoassay readers. It uses a single low power processing capacitive transimpedance amplifier architecture which includes noise cancellation. A chip containing 4 × 64 pixels was fabricated in CMOS 0.35-μm technology. With uniform illumination at 525 nm and 67 frames per second the chip has 1.9 mVrms total output referred noise and a total power consumption of 21 μW. In tests with lateral flow immunoassays the chip detected concentrations of influenza A nucleoprotein from 0.5 ng/mL to 200 ng/mL.
| Type: | Article |
|---|---|
| Title: | CMOS Image Sensor for Lateral Flow Immunoassay Readers |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1109/TCSII.2018.2855054 |
| Publisher version: | https://doi.org/10.1109/TCSII.2018.2855054 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 3.0 License. For more information, see http://creativecommons.org/licenses/by/3.0/ |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Electronic and Electrical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10053760 |
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