Tsagris, M;
Fragkos, K;
(2018)
Meta-Analyses of Clinical Trials Versus Diagnostic Test Accuracy Studies.
In: Biondi-Zoccai, G, (ed.)
Diagnostic Meta-Analysis: A Useful Tool for Clinical Decision-Making.
(pp. 31-40).
Springer: Cham, Switzerland.
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Abstract
In the present chapter, we discuss meta-analysis of clinical trials and compare them with meta-analysis of diagnostic accuracy studies. The former is based on the mixed effects model by DerSimonian and Laird (Control Clin Trials 7:177–188, 1986), and the latter is currently based on four main methods, with the most known bivariate model and the hierarchical summary receiver operator curve model. Each type of meta-analysis needs to be investigated for sources of heterogeneity. Specialist software exist to help each type of analysis.
| Type: | Book chapter |
|---|---|
| Title: | Meta-Analyses of Clinical Trials Versus Diagnostic Test Accuracy Studies |
| ISBN-13: | 978-3-319-78966-8 |
| DOI: | 10.1007/978-3-319-78966-8_4 |
| Publisher version: | https://doi.org/10.1007/978-3-319-78966-8_4 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Mixed effects model, Bivariate model, Trial, Diagnostic accuracy, Meta-analysis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10053645 |
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