Sun, Q;
Stantchev, RI;
Wang, J;
Parrott, EPJ;
Cottenden, A;
Chiu, T-W;
Ahuja, AT;
(2019)
In vivo estimation of water diffusivity in occluded human skin using terahertz reflection spectroscopy.
Journal of Biophotonics
, 12
(2)
, Article e201800145. 10.1002/jbio.201800145.
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Abstract
Water diffusion and the concentration profile within the skin significantly affect the surrounding chemical absorption and molecular synthesis. Occluding the skin causes water to accumulate in the top layer of the skin (the stratum corneum) and also affects the water diffusivity. Scar treatments such as silicone gel and silicone sheets make use of occlusion to increase skin hydration. However with existing techniques, it is not possible to quantitatively measure the diffusivity of the water during occlusion: current methods determine water diffusivity by measuring the water evaporated through the skin and thus require the skin to breathe. In this work we use the high sensitivity of terahertz light to water to study how the water content in the stratum corneum changes upon occlusion. From our measurements, we can solve the diffusion equations in the stratum corneum to deduce the water concentration profile in occluded skin and subsequently to determine the diffusivity. To our knowledge this is the first work showing how the diffusivity of human skin can be measured during occlusion and we envisage this paper as being used as a guide for non-invasively determining the diffusivity of occluded human skin in vivo.
| Type: | Article |
|---|---|
| Title: | In vivo estimation of water diffusivity in occluded human skin using terahertz reflection spectroscopy |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/jbio.201800145 |
| Publisher version: | https://doi.org/10.1002/jbio.201800145 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Water diffusivity, in vivo imaging, skin occlusion, terahertz reflection spectroscopy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10053032 |
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