Kaur, B;
Sebire, NJ;
(2018)
p57KIP2 immunostaining for diagnosis of hydatidiform mole.
BJOG
10.1111/1471-0528.15330.
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Abstract
Accurate diagnosis and sub-classification of hydatidiform moles (HM) and distinction from non-molar (NM) gestations is important, since risk of persistent gestational trophoblastic disease (pGTD) and therefore clinical management differ. P57KIP2 immunostaining has been widely described as an ancillary test to distinguish complete (CHM) and partial (PHM) hydatidiform moles, but cannot discern PHM from non-molar gestations (NM) or identify androgenetic vs biparental CHM, which may be associated with increased recurrence risk. Molecular genotyping (MG) is the gold-standard in these scenarios and also in cases with aberrant/discordant p57KIP2 expression, following which, CHM, PHM and NM can be reliably diagnosed. This article is protected by copyright. All rights reserved.
| Type: | Article |
|---|---|
| Title: | p57KIP2 immunostaining for diagnosis of hydatidiform mole. |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/1471-0528.15330 |
| Publisher version: | https://doi.org/10.1111/1471-0528.15330 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10052718 |
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