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Randomized trials and propensity score analyses in transcatheter aortic valve replacement: how should we interpret the results?

Freemantle, N; Pagano, D; (2018) Randomized trials and propensity score analyses in transcatheter aortic valve replacement: how should we interpret the results? European Journal of Cardio-Thoracic Surgery , 53 (6) pp. 1108-1111. 10.1093/ejcts/ezy120. Green open access

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Abstract

Transcatheter aortic valve replacement (TAVR) is increasingly considered an established treatment for patients with severe symptomatic aortic stenosis who are at high risk of surgical mortality or who are not suitable for surgery [1, 2]. Success in high-risk patients has inevitably raised the potential to extend the use of TAVR technology to lower risk subjects, fuelled by both clinician innovation and commercial interests. The evidence base to support this development has included randomized trials and quasi-experimental propensity score based analyses. In this article, we discuss the landmark available studies (summarized in Table 1), their strengths and limitations, and make some general evidence based recommendations on their interpretation.

Type: Article
Title: Randomized trials and propensity score analyses in transcatheter aortic valve replacement: how should we interpret the results?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/ejcts/ezy120
Publisher version: http://doi.org/10.1093/ejcts/ezy120
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > Comprehensive CTU at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10052583
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