Freemantle, N;
Pagano, D;
(2018)
Randomized trials and propensity score analyses in transcatheter aortic valve replacement: how should we interpret the results?
European Journal of Cardio-Thoracic Surgery
, 53
(6)
pp. 1108-1111.
10.1093/ejcts/ezy120.
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Abstract
Transcatheter aortic valve replacement (TAVR) is increasingly considered an established treatment for patients with severe symptomatic aortic stenosis who are at high risk of surgical mortality or who are not suitable for surgery [1, 2]. Success in high-risk patients has inevitably raised the potential to extend the use of TAVR technology to lower risk subjects, fuelled by both clinician innovation and commercial interests. The evidence base to support this development has included randomized trials and quasi-experimental propensity score based analyses. In this article, we discuss the landmark available studies (summarized in Table 1), their strengths and limitations, and make some general evidence based recommendations on their interpretation.
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