McGinnity, CJ;
Barros, DAR;
Trigg, W;
Brooks, DJ;
Hinz, R;
Duncan, JS;
Koepp, MJ;
(2018)
Simplifying [F-18]GE-179 PET: are both arterial blood sampling and 90-min acquisitions essential?
EJNMMI Research
, 8
, Article 46. 10.1186/s13550-018-0396-2.
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Abstract
Introduction The NMDA receptor radiotracer [18F]GE-179 has been used with 90-min scans and arterial plasma input functions. We explored whether (1) arterial blood sampling is avoidable and (2) shorter scans are feasible. Methods For 20 existing [18F]GE-179 datasets, we generated (1) standardised uptake values (SUVs) over eight intervals; (2) volume of distribution (VT) images using population-based input functions (PBIFs), scaled using one parent plasma sample; and (3) VT images using three shortened datasets, using the original parent plasma input functions (ppIFs). Results Correlations with the original ppIF-derived 90-min VTs increased for later interval SUVs (maximal ρ = 0.78; 80–90 min). They were strong for PBIF-derived VTs (ρ = 0.90), but between-subject coefficient of variation increased. Correlations were very strong for the 60/70/80-min original ppIF-derived VTs (ρ = 0.97–1.00), which suffered regionally variant negative bias. Conclusions Where arterial blood sampling is available, reduction of scan duration to 60 min is feasible, but with negative bias. The performance of SUVs was more consistent across participants than PBIF-derived VTs.
| Type: | Article |
|---|---|
| Title: | Simplifying [F-18]GE-179 PET: are both arterial blood sampling and 90-min acquisitions essential? |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/s13550-018-0396-2 |
| Publisher version: | https://doi.org/10.1186/s13550-018-0396-2 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Radiology, Nuclear Medicine & Medical Imaging, NMDA, PET, Compartmental modelling, CNS-5161, SUV, RECEPTORS, BINDING, QUANTIFICATION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10051871 |
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