Novakova, L;
Singh, AK;
Axelsson, M;
Ståhlman, M;
Adiels, M;
Malmeström, C;
Zetterberg, H;
... Blomqvist, M; + view all
(2018)
Sulfatide isoform pattern in cerebrospinal fluid discriminates progressive MS from relapsing‐remitting MS.
Journal of Neurochemistry
, 146
(3)
pp. 322-332.
10.1111/jnc.14452.
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Abstract
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Several biomarkers including proteins and lipids have been reported in MS cerebrospinal fluid (CSF), reflecting different aspects of the pathophysiology particularly of relapsing‐remitting MS (RRMS). Sulfatide, abundant in the myelin sheath and a proposed target for autoimmune attack in MS, has been reported altered in MS CSF. Here, we investigated the potential of CSF sulfatide and its isoforms as biomarkers in MS. A highly sensitive and quantitative mass spectrometry method was employed to determine levels of sulfatide isoforms in CSF from RRMS and progressive MS (PMS) patients, and healthy donors (HD). We demonstrate that levels of total CSF sulfatide and C24:1, C26:1, and C26:1‐OH isoforms were significantly increased in PMS compared with RRMS patients and HD, while C23:0‐OH was significantly decreased in CSF from PMS patients compared to the other two groups. Multivariate discriminant analysis showed that CSF sulfatide isoform pattern in PMS patients was distinct and non‐overlapping with that of RRMS patients and HD. Sulfatide levels did not correlate with tested biomarkers or clinical parameters. The results suggest that CSF sulfatide isoform levels may be used to discriminate the phenotype of MS and might play a role in the progression of the disease.
| Type: | Article |
|---|---|
| Title: | Sulfatide isoform pattern in cerebrospinal fluid discriminates progressive MS from relapsing‐remitting MS |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/jnc.14452 |
| Publisher version: | https://doi.org/10.1111/jnc.14452 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | axonal loss, biomarkers, cerebrospinal fluid, demyelination, inflammation, mass spectrometry, multiple sclerosis, sulfatide |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10051550 |
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